For research and educational purposes only. Not medical advice.
Fisetin Reference
Educational, not medical advice reference for Fisetin: Longevity; regulatory status, evidence posture, source review, and schedule notes. Also known as 3,3',…
Reference summary
Yousefzadeh 2018 EBioMedicine reported senolytic activity and modest lifespan extension in mouse models. Human outcome data are not yet available; AFFIRM-LITE is the registered Phase 2 trial in older adults.
Regulatory and posture
- Categories
- Longevity
- Aliases
- 3,3',4',7-tetrahydroxyflavone, Senolytic flavonoid (OTC dietary supplement)
- Evidence posture
- preclinical - Mostly animal data. Human outcome trials have not reported.
- Regulatory status
- Over-the-counter dietary supplement in the United States. Not FDA-approved as a drug for any indication. The AFFIRM-LITE Phase 2 trial (NCT03675724) is enrolling but has not reported outcome data.
- Content review status
- research reference