GLPG0492 Reference
Educational, not medical advice reference for GLPG0492: SARM, Recovery; regulatory status, evidence posture, source review, and schedule notes.…
Plain English
- What it is
- GLPG0492 is a SARM, a lab-made drug built to target the body's muscle-building hormone signals while trying to spare other tissues. It is sold only as a research chemical, not as an approved medicine.
- What people use it for
- A few people in bodybuilding and body 'recomp' circles are curious about it for holding on to muscle. That interest is based on talk and guesswork, not proof, and keeping or building muscle is not an approved use.
- What the science shows
- Almost all the published research is in mice, mostly muscle-disease and muscle-wasting models, not people. A drug company did begin one early, small first-in-human safety study years ago, but no human results showing it works have been published and there is no human efficacy program.
- The catch
- The FDA has warned the public against SARMs, which are not approved and are sold illegally in bodybuilding and supplement products, and global sport bans them at all times as S1.2 anabolic agents. Reported SARM risks include lower natural testosterone, liver strain, and effects on cholesterol and the heart. Safety in people, and even what is really inside products sold under this name, has not been established.
Reference summary
Published evidence centers on mouse muscular-dystrophy and hindlimb-immobilization models plus doping-control metabolism work. Human outcome data are absent.
Regulatory and posture
- Categories
- SARM, Recovery
- Aliases
- GLPG-0492, DT-200, Non-steroidal SARM
- Evidence posture
- preclinical - Preclinical-only SARM. Community interest in muscle preservation is speculative and extrapolated from animal models. Doping-control papers do not establish safety or efficacy. WADA-prohibited; no FDA approval.
- Regulatory status
- No FDA-approved GLPG0492 drug label. FDA consumer warnings against SARMs sold in bodybuilding products apply to the class. WADA prohibits SARMs under category S1.2 anabolic agents at all times.
- Content review status
- research reference
Selected public sources
- FDA consumer update: SARMs are not FDA-approved and cannot be legally marketed as dietary supplements
- WADA prohibited list: SARMs are category S1.2 anabolic agents prohibited at all times
- PubMed: GLPG0492 exercised-mdx mouse muscular-dystrophy model
- PubMed: GLPG0492 mouse hindlimb-immobilization model
- PubMed: GLPG0492 equine metabolism study for doping control
Related tools
- Protocol builder overview - Public overview of the Pro protocol builder.
For research and educational purposes only. Not medical advice.