PF-06260414 Reference

Plain English

What it is

PF-06260414 is a SARM, which is a lab-made drug built to switch on the body's muscle-building hormone signals while trying to avoid some side effects of regular steroids. It is a drug-company research compound, sold only as a research chemical and not as an approved medicine.

What people use it for

In bodybuilding, recomp, and fat-loss circles people mention it as a less common drug-company SARM and try it to add muscle or lean out. This is anecdotal community use, not an approved or proven use.

What the science shows

Pfizer ran an early first-in-human study that checked safety and how the body handles the compound. That study did not lead to an approved medicine or any proven plan for changing body shape, and the compound does not appear in the company's current pipeline. Community use goes far beyond what that small study actually tested.

The catch

The FDA has warned the public against SARMs, which are not approved for human use and are often sold illegally and mislabeled, and WADA bans SARMs in sport at all times as S1.2 anabolic agents. Even in the controlled human study, liver enzyme (ALT) increases were among the most common side effects, and the drug lowered total testosterone and HDL (good) cholesterol, pointing to real risks of liver strain, hormone suppression, and cholesterol changes.

Reference summary

A first-in-human safety, pharmacokinetic, and pharmacodynamic study exists. It did not establish an approved indication or a validated body-composition program.

Regulatory and posture

Categories

SARM

Aliases

PF06260414, Pfizer SARM, Non-steroidal SARM

Evidence posture

human - Human safety / PK work exists, but no approved product followed. ALT changes were reported in the published safety work. WADA-prohibited; no FDA approval and no validated gym-use program.

Regulatory status

No FDA-approved PF-06260414 drug label. FDA consumer warnings against SARMs sold in bodybuilding products apply to the class. WADA prohibits SARMs under category S1.2 anabolic agents at all times.

Content review status

research reference