Plecanatide Reference

Plain English

What it is

Plecanatide is a prescription medicine sold under the brand name Trulance. It is approved by the U.S. Food and Drug Administration (FDA). It is a guanylate cyclase-C agonist, a drug that acts inside the gut to move things along.

What people use it for

Doctors prescribe it for adults who have long-term constipation with no clear cause, and for irritable bowel syndrome with constipation (a gut condition where being constipated is a main symptom). It is the same type of medicine as linaclotide, sold as Linzess.

What the science shows

Because it is a fully approved medicine, it has been tested in people and reviewed by regulators before reaching the market. The side effect reported most often is diarrhea.

The catch

It is not allowed for children under 6 years old because it can cause serious dehydration, meaning a dangerous loss of body fluid, and its use is also avoided in kids and teens under 18. This is a prescription constipation medicine, not a research peptide or a stack ingredient.

Reference summary

Plecanatide is a label-verified guanylate cyclase-C agonist in the same class as linaclotide. pepSmart surfaces label-reference content only.

Regulatory and posture

Categories

GI

Aliases

Trulance, Guanylate cyclase-C agonist

Evidence posture

human

Regulatory status

FDA-approved prescription medication (Trulance). Indicated for chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. Boxed warning against use in pediatric patients under 6 years.

Content review status

label verified