For research and educational purposes only. Not medical advice.
Spermidine Reference
Educational, not medical advice reference for Spermidine: Longevity; regulatory status, evidence posture, source review, and schedule notes. Also known as Po…
Reference summary
The SmartAge program (Wirth/Schwarz 2019 Alzheimers Res Ther pilot; Schwarz 2022 JAMA Network Open 12-month RCT) tested wheat-germ-extract spermidine supplementation in older adults with subjective cognitive decline. The 2022 RCT did not show a significant cognitive benefit over placebo. No outcome trial has demonstrated longevity benefit in humans.
Regulatory and posture
- Categories
- Longevity
- Aliases
- Polyamine, Wheat-germ extract (typical dietary source), OTC dietary supplement
- Evidence posture
- human - Pilot and one 12-month RCT only; the RCT was null on cognition.
- Regulatory status
- Over-the-counter dietary supplement in the United States. Not FDA-approved as a drug for any indication.
- Content review status
- research reference