For research and educational purposes only. Not medical advice.

Glutathione Reference

Educational, not medical advice reference for Glutathione: Longevity, Recovery; regulatory status, evidence posture, source review, and schedule…

Reference summary

Glutathione is the endogenous tripeptide (gamma-glutamyl-cysteinyl-glycine) and the cell's principal intracellular antioxidant. Oral glutathione bioavailability is poor because of intestinal hydrolysis; injectable preparations bypass that limitation. The Hauser 2009 Movement Disorders double-blind pilot of intravenous glutathione in early Parkinson disease reported a modest non-significant improvement in motor symptoms. Other small open-label series have reported mixed signals. No large outcome trial supports the community-cited longevity, skin-lightening, or detox indications.

Regulatory and posture

Categories
Longevity, Recovery
Aliases
GSH, L-glutathione, Reduced glutathione, IV glutathione, Glutathione infusion, SubQ glutathione
Evidence posture
translational - Endogenous antioxidant biology is real; injectable-glutathione human evidence for the community-cited indications is limited to small trials and open-label series. Compounded injection products are not FDA-approved and sterility / dose-accuracy depend on the compounder. Serious adverse events (anaphylaxis, Stevens-Johnson syndrome) have been reported with skin-lightening intravenous use.
Regulatory status
No FDA-approved injectable glutathione drug label exists for the anti-aging, skin-lightening, liver-detox, or hangover-recovery indications the product is marketed for. Compounded intravenous and subcutaneous glutathione preparations are sold by IV-therapy clinics and research-chemical sellers. The US FDA has flagged compounded preparations in its peptide-compounding safety communications, and the Philippines FDA issued a 2011 public warning against intravenous glutathione for skin whitening after serious adverse-event reports.
Content review status
research reference

Selected public sources

Related tools